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KMID : 0043319980210050559
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.559 ~ p.564
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Synthesis and Pharmacokinetic Profile of 3-Methoxymethyl Cephalosporin Prodrugs
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Jung Myung-Hee
Cho Kui-Woong
Park Jewn-Giew
Kim Young-Hee
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Abstract
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Preparation and biological activity of prodrug-type 3-methoxymethyl cephalosporins were described. From the mixtures, R- and S-prodrugs were separated and their absolute configurations were determined, and also their bioavailability was investigated.
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KEYWORD
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3-Methoxymethylcephalosporins, Prodrug, Cycloalkylcarbonatesxyethyl, Oral cephalosporin
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